Biologically active secondary metabolites of an endophytic fungus of Psidium guajava

Endophytes possess several phytohormones and bioactive metabolites of medicinal importance thus, continue to generate research interest as candidates in drug discovery programmes. This study was carried out investigate the secondary an endophytic fungus isolated from leaves Psidium guajava. Endophytic fungal isolation, fermentation; extraction ethyl acetate were using standard methods. The crude extract subjected Vacuum Liquid Chromatography (VLC) binary combinations Hexane:Ethyl Dichloromethane:Methanol obtain fourteen sub-fractions designated PG55-1 PG55-14. extracts VLC screened for antimicrobial activity also high-performance liquid chromatography-diode-array detection (HPLC-DAD) analysis identification compounds. An fungus, PG55 leaf showed antibacterial properties, with minimum inhibitory concentrations ranging 0.0625 – 1 mg/ml. No antifungal observed. HPLC-DAD suggested presence p-hydroxybenzoic acid, pentenedioic acid palitantin one fractions PG55. Some these compounds are known agents may be responsible activities recorded extracts. results this study, suggests many potentials possessed by Nigerian plants hosts endophytes that could reservoirs excellent sources pharmacologically active